Endocrine Abstracts

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) has caused millions of deaths worldwide, thus a massive SARS-CoV-2 vaccination campaign has been launched since the end of 2020. Viruses and vaccines can induce adverse thyroid effects; SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT) and Graves’ disease (GD). We aimed to study the occurrence o...

Background: The Covid-19 pandemic caused by the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) determined millions of deaths worldwide, thus at the end of 2020 a massive vaccination campaign has been launched. SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT), Graves’ disease (GD) and orbitopathy (GO). We studied the occurrence of SAT and GO following SARS-CoV-2 infection or vaccinati...

Introduction: The humanized antibody anti-CD52+ alemtuzumab has been approved since 2014 for the treatment of relapsing-remitting multiple sclerosis (RRMS). Immune reconstitution after alemtuzumab induces thyroid autoimmunity in 34-41% of patients with RRMS, with Graves’ disease (GD) accounting for 63-65% of cases. Graves’ Orbitopathy (GO) may also occur in 13% of patients after alemtuzumab and is scarcely reported. Here we present the first case of alemtuzumab-induc...

Background: Vaccination is a widely adopted measure against the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) causing Covid-19 pandemic. Both SARS-CoV-2 infection and Covid-19 vaccines have been associated with several thyroid disorders. We studied the risk of Graves’ orbitopathy (GO) following Covid-19 vaccination.Methods: The study included 98 consecutive patients (71 females and 27 males, mean-age 50 years) attending our tertiary r...

Objectives: During the Covid-19 pandemic caused by the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2), vaccination has been widely adopted. Both SARS-CoV-2 infection and Covid-19 vaccines have been associated with several thyroid disorders. We studied the risk of Thyroid Eye Disease (TED) following Covid-19 vaccination.Methods: This self-controlled-case-series study, validated model in assessing vaccine safety, included 98 consecutive patie...

Introduction: A possible association between the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 pandemic, in terms of infection and/or vaccination, and subacute thyroiditis (SAT) has been recently reported. Although a higher SAT incidence in pandemic has been described, data are still conflicting.Aim: To determine SAT incidence in Italy during the SARS-CoV-2 pandemic and to characterize clinical peculiarities and response to medical treatment...

Background and Aims: Graves’ disease (GD) and orbitopathy (GO) are characterised by the presence of pathological anti-thyrotropin receptor antibodies. In thyroid autoimmunity, especially GD and GO, a dysregulation of several T cell subpopulations has been proposed, especially T regulatory (Treg) and T helper 17 (Th17) cells, determining (auto)immunity inhibition and enhancement, respectively. T follicular cells (Tf) within germinal centres (GC: aggregates of lymphocytes w...

Objectives: In Graves’ disease (GD) and Graves’ orbitopathy (GO) self-reactive lymphocytes escape immune tolerance, although the underlying mechanisms are not fully understood. We aimed to characterize the immune signatures of target tissue-resident lymphocytes in relation to GD and GO.Methods: Lymphocytes were derived from blood and ultrasound-guided-fine-needle aspiration (US-FNA) of thyroid and neck lymph nodes (LNs) of the following patient...